The following information shows just how safe the Nerium AD Age Defying Cream is:
To summarize the safety of Nerium:
To share a comment on NeriumAD as it relates to children, the Pediatric MD, Pharmacologist/Toxicologist panelist commented that if a 1-year-old child ate the full contents of 400 bottles of NeriumAD, the child would still only reach a non-toxic dose of NeriumAD.
Safety Starts on the Farm
Safety for Nerium SkinCare products start at the company owned Farming Operations. Fields of Nerium oleander plants (a specific variety) are harvested for the raw plant material utilized in our extraction processing.
Utilizing strict biomedical field protocols, the farm provides a dedicated and renewable biomass resource reserved exclusively for biotechnology research, product development, and product production. Analytical testing for safety begins at the field level and is performed by independent third parties. Prior to harvest, analytical testing is performed for identification of specific components of the plant and includes testing for levels of metals and pesticides. After the processing/milling of the raw plant material, the Nerium oleander powder biomass is again tested for specific components and microbiology for aerobic count, etc.
GMP manufacturing provides for testing at every phase of product production. The first phase is the Nerium oleander biomass extraction process that provides the Nerium extract ingredient (NAE-8â„¢) that is then tested for specific plant components, micro, etc. as are all additional ingredients. Testing continues after each process, cream manufacturing, filling/packaging, and all the way to the finished product. Upon completion of the manufacturing process, the finished product is once again tested by an additional third party laboratory for specific Nerium oleander components to ensure safety and quality. In addition, batch samples for each production run are retained for testing at various intervals thereafter.
With the primary goal of product safety and quality, Nerium SkinCare has taken great care with respect to the safety of their lead product NeriumAD. With the identification of potential topical applications from research on Nerium oleander extracts, Nerium SkinCare contracted with ST&T Research (Science, Technology, and Toxicology) to provide additional research and a series of clinical trials for safety and efficacy over a 5-year period (2008-2012). In each clinical trial safety parameters were set to assess efficacy and evidence of any adverse reactions, which included detailed studies of the product’s key ingredients to determine if there was absorption through the skin barrier into the blood. The study protocols compared baseline and weekly testing of study participants utilizing an extremely powerful LC/MS/MS analytical instrumentation (capable of detecting nano-gram sized concentrations) which generated data that confirmed no detectable levels of the of the ingredients were found in the blood. The ST&T clinical data from the NeriumAD clinical trial confirmed safety.
As confirmation of ST&T data and results, Nerium SkinCare provided these findings along with other data from the world literature to an independent group of MD and PhD Pharmacologist/Toxicologist to review the literature and all clinical data on Nerium oleander and NeriumAD. The determination of this group is that NeriumAD is safe.
In addition Nerium SkinCare has presented research, clinical and safety results at various meetings. As an example, a panel discussion of NeriumAD was presented at the Annual Meeting of the North American Congress of Clinical Toxicology ¦ (NeriumAD Safety Panel Presentation/Discussion). A group of five scientists included MD’s, Pediatrician toxicologists/pharmacologists and PhD’s, who are professors of Pharmacology and Toxicology and directors of US poison control centers, one of the five is a MD, Ph.D. pharmacologist/toxicologist and a former Medical Officer for the Food and Drug Administration. It’s needless to say, a very distinguished panel with the ability and credibility to speak to safety; and recognized members of the North American Congress of Clinical Toxicology.
The presentation/discussion included the review of Dr. Newman’s research and ST&T clinical data, a review of the database of the American Association of Poison Control Centers as it relates to Nerium oleander, data from the world literature, and a discussion regarding some of the myths about Nerium oleander which have sprung up in folklore. Also discussed was the potential toxicity of NeriumAD as it relates to accidental ingestion by children, and a relative risk comparison to other safe products that are also known to contain natural occurring toxic compounds. The conclusion of this panel is that NeriumAD is safe. To share a comment on NeriumAD as it relates to children, the Pediatric MD, Pharmacologist/Toxicologist panelist commented that if a 1-year-old child ate the full contents of 400 bottles of NeriumAD, the child would still only reach a non-toxic dose of NeriumAD.
As a commitment to quality, Nerium SkinCare will not compromise on the quality of our products. The quality of Nerium’s products is a direct result of the investment made into its people, the scientific research, new technology development, natural farming methods, biomass processing, cGMP production facilities, product safety testing, and independent verification.